α₁-Antitrypsin deficiency associated with increased risk of heart failure

Individuals with α 1 -antitrypsin deficiency have increased elastase activity resulting in continuous degradation of elastin and early onset chronic obstructive pulmonary disease. Increased may also affect elastic properties the heart, which impact risk heart failure. We tested hypothesis that is associated failure two large populations. In a nationwide nested study 2209 patients 21 869 controls without matched on birthday, sex, municipality, we recorded admissions deaths due to during median follow-up 62 years. studied population-based cohort another 102 481 individuals from Copenhagen General Population Study including 187 Danish -Antitrypsin Deficiency Registry, all genetically confirmed deficiency. versus had risks hospitalization (adjusted hazard ratio: 2.64; 95% CI: 2.25–3.10) (1.77; 1.14–2.74). Nationwide, these ratios were highest those myocardial infarction (3.24; 2.70–3.90), aortic valve stenosis (2.80; 2.38–3.29), hypertension (3.44; 2.81–4.22), atrial fibrillation (3.33; 2.75–4.04), any four diseases (6.00; 4.60–7.82). Hazard for failure-specific mortality 2.28 (1.57–3.32) 3.35 (1.04–10.74) cohort. conclusion, population.